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KMID : 0369820050350010025
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 1 p.25 ~ p.31
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Anti-tumour Efficiency of Chitosan Hydrogel Containing Anionic Liposomes as a Depot System
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최민수/Choi MS
한희동/김태우/송충길/박은석/신병철/Han HD/Kim TW/Song CK/Park ES/Shin BC
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Abstract
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Depot system for local drug delivery using chitosan hydrogel has been developed to enhance the therapeutic efficacy and to prevent the severe side effect in whole body. Thus, we have prepared an injectable chitosan hydrogel containing liposomes to treat cancers clinically. Anionic liposomes incorporated to improve sustained release efficiency within chitosan hydrogel. The chitosan solution containing liposomes was designed to form a hydrogel complex at body temperature. The released behavior of doxorubicin from liposomes in chitosan hydrogel showed sustained-release caused by diffusion of doxorubicin from temperature responsive liposome into chitosan hydrogel. The chitosan hydorgel containing liposomes enhanced the therapeutic potency for the solid tumor in vivo system. Our results indicate that the liposomes in chitosan hydrogel represent a depot system for local drug delivery.
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KEYWORD
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Chitosan, Liposome, Hydrogel, Doxorubicin, Depot system
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